林明焰

来源:澳门新葡8455手机版 发布者:张愉悦发布时间:2018-04-02浏览次数:1079

林明焰 副教授 理学博士 硕士生导师

科学研究方向

计算生物学,生物信息学,多基因组学,人工智能,脑科学和精神疾病学,神经组学

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166

电话:15715150282

电邮:linmingyan@njmu.edu.cn



简介

主要通过多组学技术对脑神经系统,肿瘤和心血管等人类重大疾病的基因病变机理进行探索。目前主要通过基因组学、生物信息学和大数据科学探究人脑高度进化的生物学根源,解析人脑复杂成分的细胞学基础,发展新一代脑机智能技术,阐释脑重大疾病的致病机理,确立精神疾病预警和早期诊断的指标。已发表SCI文章25篇,其中一作文章14篇,一作文章的累计影响因子(按发表当年的影响因子计算)为58.4,平均影响因子为5.1,单篇最高影响因子为10.19,一作文章的总引用次数为351,平均单篇引用次数为52,单篇最高引用次为224。


教育背景及工作经历

2003-2007  南京大学 本科

2008-2010  美国俄克拉荷马大学 硕士

2010-2016  美国爱因斯坦医学院 博士

2017-至今   澳门新葡8455最新网站  副教授


承担科研课题

1. 国家自然科学青年基金(81701320),“精神分裂症易感基因TCF4在神经发育阶段调控机理研究“,2018/01-2020/12,  20万元,在研,主持

2. 江苏省基础研究计划(自然科学基金)--青年基金项目(BK20171062),“精神分裂症易感基因在早期神经发育阶段相互作用机制研究”,2017/07-2020/06, 20万元,在研,主持

3. 江苏省高等学校自然科学研究面上项目(17KJB180009),“精神分裂症与神经发育障碍的研究”,2017/07-2019/06, 3万元,在研,主持

4. 澳门新葡8455最新网站引进人才科研启动基金(XZ21614153),“精神分裂症早期易感状态的研究”,2017/01 -2020/12,60万元,在研,主持  


近五年代表性论文、专利

1. Lin M(#), Pedrosa E, Hrabovsky A, Chen J, Puliafito BR, Gilbert SR, Zheng D(*), Lachman HM(*): Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion. BMC Syst Biol 2016, 10:105.

2. Wang P(#), Lin M(#), Pedrosa E, Hrabovsky A, Zhang Z, Guo W, Lachman HM(*), Zheng D(*): CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment. Mol Autism 2015, 6:55.

3. Mi S(#), Lin M(#), Brouwer-Visser J, Heim J, Smotkin D, Hebert T, Gunter MJ, Goldberg GL, Zheng D, Huang GS(*): RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma. Clin Cancer Res 2016, 22:4676-4686.

4. Lin M(#), Lachman HM, Zheng D(*): Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders. Mol Cell Neurosci 2016, 73:32-42.

5. Chen J(#), Lin M(#), Foxe JJ, Pedrosa E, Hrabovsky A, Carroll R, Zheng D, Lachman HM(*): Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts. PLoS One 2013, 8:e75682.

6. Zhao J(#), Zhang W(#), Lin M(#), Wu W, Jiang P, Tou E, Xue M, Richards A, Jourd'heuil D, Asif A, Zheng D, Singer HA, Miano JM, Long X(*): MYOSLID Is a Novel Serum Response Factor-Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program. Arterioscler Thromb Vasc Biol 2016, 36(10):2088-2099.

7. Lin M(#), Zhao D, Hrabovsky A, Pedrosa E, Zheng D(*), Lachman HM(*): Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon. PLoS One 2014, 9:e94968.

8. Zhao D(#), Lin M(#), Chen J, Pedrosa E, Hrabovsky A, Fourcade HM, Zheng D(*), Lachman HM(*): MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11. 2 Del. PLoS One 2015, 10:e0132387.

9. Bell RD(#), Long X(#), Lin M(#), Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D(*), Miano JM(*): Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. Arterioscler Thromb Vasc Biol 2014, 34:1249-1259.

10. Chen J(#), Lin M(#), Hrabovsky A, Pedrosa E, Dean J, Jain S, Zheng D, Lachman HM(*): ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin. PLoS One 2015, 10:e0124597.

11. Huang, Q.#, Y. Chen, S#. Shen, Y. Wang, L. Liu, S. Wu, W. Xu, W. Zhao, M. Lin* and J. Wu* (2020). "Klotho antagonizes pulmonary fibrosis through suppressing pulmonary fibroblasts activation, migration, and extracellular matrix production: a therapeutic implication for idiopathic pulmonary fibrosis." Aging 12.




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