1An   essential role for PNLDC1 in piRNA 3' end trimming and male fertility in   mice.
Cell   Res. 2017 Nov;27(11):1392-1396张越 

沙家豪 叶岚  


2The   histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis   in mice.
Hepatology.   2017 Jun;65(6):1904-1919樊智文 徐涌 沈爱国病理生理学13.246
3Innate   scavenger receptor-A regulates adaptive T helper cell responses to pathogen   infection.
Nat   Commun. 2017 Jul 11;8:16035徐志鹏陈晓军 苏川病原生物学12.124
4The   histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial   infarction.
Nat   Commun. 2017 Mar 31;8:14941杨光 徐涌 孙爱军病理生理学12.124
5H3K27   acetylation activated-long non-coding RNA CCAT1 affects cell proliferation   and migration by regulating SPRY4 and HOXB13 expression in esophageal   squamous cell carcinoma.
Nucleic   Acids Res. 2017 Apr 7;45(6):3086-3101张二宝 

德伟  Lin Xu

束永前 陈锦飞

6TCTE1   is a conserved component of the dynein regulatory complex and is required for   motility and metabolism in mouse spermatozoa.
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7Scavenger   Receptor A1 Prevents Metastasis of Non-Small Cell Lung Cancer via Suppression   of Macrophage Serum Amyloid A1.
Cancer   Res. 2017 Apr 1;77(7):1586-1598.张艳 陈琪 贲晶晶病理生理学9.122
8Mechanistic   study of CBT-Cys click reaction and its application for identifying bioactive   N-terminal cysteine peptides in amniotic fluid.
Chem   Sci. 2017 Jan 1;8(1):214-222郑珍 

王富强 黄光明


9The   E3 ubiquitin ligase RNF114 and TAB1 degradation are required for   maternal-to-zygotic transition.
EMBO   Rep. 2017 Feb;18(2):205-216杨烨 霍然 李卫组织胚胎学8.568
10Sleep   homeostasis regulated by 5HT2b receptor in a small subset of neurons in the   dorsal fan-shaped body of drosophila.
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11A viral microRNA downregulates metastasis suppressor CD82 and induces cell   invasion and angiogenesis by activating the c-Met signaling.
Oncogene.   2017 Sep 21;36(38):5407-5420李婉 卢春病原生物学7.519
12Synergistic   Suppression of Tumor Angiogenesis by the Co-delivering of Vascular Endothelial Growth Factor Targeted siRNA and Candesartan Mediated by   Functionalized Carbon Nanovectors

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13Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor.
ACS   Appl Mater Interfaces. 2017 Apr 19;9(15):13068-13078吴艺舟 张根 He N 
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14Aberrant   Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of CaV1.2  Calcium Channel and Vascular Myogenic Tone in Hypertension.
Hypertension.   2017 Dec;70(6):1183-1192周盈盈 王觉进生理学6.857
15Angiogenic   Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.
Arterioscler   Thromb Vasc Biol. 2017 Apr;37(4):675-684周必胜徐涌 夏俊病理生理学6.607
16Epigenetic   Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis,
Front   Immunol. 2017 Jan 30;7:696胡丽 陈峰法医学6.429
171,25-Dihydroxyvitamin   D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via   Targeting the NF-E2-Related Factor 2-Hemeoxygenase-1-HMGB1 Pathway in Macrophages.
Front   Immunol. 2017 Oct 16;8:1308饶泽兵陈允梓免疫学6.429
18Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT-1 via σ1 receptor-mediated PKC activation in the hippocampal dentate gyrus of rats.
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19Activation of Transient Receptor Potential Vanilloid 4 Promotes the Proliferation of   Stem Cells in the Adult Hippocampal Dentate Gyrus.
Mol   Neurobiol. 2017 Oct;54(8):5768-5779田玉静陈蕾生理学6.19
20Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced  Depression Through Restoring Hippocampal nNOS-NO-CREB Activities   in Mice.
Mol   Neurobiol. 2017 May;54(4):3017-3030. 张苏云 陈玲 吴洁生理学6.19
21Caspase-1   Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting   Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Mol   Neurobiol. 2017 Aug;54(6):4292-4302乔晨胡刚药理学6.19
22AMPK   activation by peri-sciatic nerve administration of ozone attenuates   CCI-induced neuropathic pain in rats.
J   Mol Cell Biol. 2017 Apr 1;9(2):132-143陆丽娟 

刘文涛 程志祥


23HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α   ubiquitylation and degradation.
Cell   Death Dis. 2017 Dec 11;8(12):3202黄玉洁梁秀彬病理生理学5.965
24Salusin-β   contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Cell   Death Dis. 2017 Mar 23;8(3):e2690赵明霞朱国庆生理学5.965
25BCL6 attenuates renal inflammation via negative regulation of NLRP3 transcription.
Cell   Death Dis. 2017 Oct 26;8(10):e3156.陈丹朱国庆生理学5.965
26NLRP3   inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.
Cell   Death Dis. 2017 Oct 5;8(10):e3074孙海建朱国庆生理学5.965
27Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice.
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28IL-17-triggered   downregulation of miR-497 results in high HIF-1α expression and consequent   IL-1β and IL-6 production by astrocytes in EAE mice.
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29The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation.
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30Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.
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31MHC II-, but not MHC II+, hepatic Stellate cells contribute to liver fibrosis of mice in infection with Schistosoma japonicum.
Biochim   Biophys Acta. 2017 Jul;1863(7):1848-1857.周春雷王勇病原生物学5.476
32Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.
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33GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss.
J   Med Genet. 2017 Jun;54(6):426-430邢光前 曹新生物技术5.451
34TIMP-1 and CD82, a promising combined evaluation marker for PDAC.
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35Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor   development in vitro and in vivo.
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36Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra.
Neurobiol   Aging. 2017 Nov;59:171-183洪娟陈玲生理学5.117
37Angiotensin-(1-7)   in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic   Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats
Cell   Physiol Biochem. 2017;42(6):2523-2539任兴胜韩莹生理学5.104
38Osterix Decreases the Chemosensitivity of Breast Cancer Cells by Upregulating   GALNT14.
Cell   Physiol Biochem. 2017;44(3):998-1010吴佳慧 马长艳发育遗传学5.104
39NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling.
Cell   Physiol Biochem. 2017 Dec 14;44(6):2269-2280.任兴胜朱国庆生理学5.104
40Lidocaine   alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord.
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41Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation.
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42Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome   suppression.
J   Neuroinflammation. 2017 Apr 4;14(1):74刘海娇 刘文涛药理学5.102
43Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine   attenuates neuropathic pain in rats.
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44Activation of Transient Receptor Potential Vanilloid 4 Impairs the Dendritic Arborization of Newborn Neurons in the Hippocampal Dentate Gyrus through the AMPK and Akt Signaling Pathways.
Front   Mol Neurosci. 2017 Jun 15;10:190田玉静 陈蕾生理学5.076
45MPTP-reduced dopaminergic afferent in basolateral amygdala causes down-regulation of GABAA receptors and LTD impairment.
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46Hyperactivity of hypothalamic-pituitary-adrenal axis due to dysfunction of the hypothalamic glucocorticoid receptor in sigma-1 receptor knockout mice.
Front   Mol Neurosci. 2017 Sep 6;10:287狄婷婷陈玲生理学5.076
47Rosiglitazone exerts an anti-depressive effect in unpredictable chronic mild-stress-induced depressive mice by maintaining essential neuron autophagy and inhibiting excessive astrocytic apoptosis
Front   Mol Neurosci. 2017 Sep 14;10:293.赵展孙秀兰药理学5.076
48Acetylation of MKL1 by PCAF regulates pro-inflammatory transcription.
Biochim   Biophys Acta. 2017 Aug;1860(8):839-847于黎明徐涌病理生理学5.018
49Sigma-1 receptor deficiency reduces GABAergic inhibition in the basolateral amygdala  leading to LTD impairment and depressive-like behaviors.
Neuropharmacology.   2017 Apr;116:387-398张宝峰陈玲 王军生理学5.012
50PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Neuropharmacology.   2017 Feb;113(Pt A):396-406季娟 孙秀兰药理学5.012
51Lis1   Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation.
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52Sublytic  C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway   of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis.
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53Salusin-β   Is Involved in Diabetes Mellitus-Induced endothelial dysfunction via degradation of peroxisome proliferator-activated receptor gamma
Oxidative   Medicine and Cellular Longevity.2017,Nov19;2017: Article ID 6905217孙海建 张枫生理学4.593
54RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.
Biochem   Pharmacol. 2017 Mar 1;127:34-45陈峰陈峰 Fulton D法医学4.581
55Glycine   prevents pressure overload induced cardiac hypertrophy mediated by glycine   receptor.
Biochem   Pharmacol. 2017 Jan 1;123:40-51陆艳 陈琪病理生理学4.581
56Icariin   protects against glucocorticoid induced osteoporosis, increases the  expression of the bone enhancer DEC1 and modulates the   PI3K/Akt/GSK3β/β-catenin integrated signaling pathway.
Biochem   Pharmacol. 2017 Jul 15;136:109-121胡锦华杨俭药理学4.581
57Vascular   endothelial growth factor promotes the activation of hepatic stellate cells   in chronic schistosomiasis.
Immunol   Cell Biol. 2017 Apr;95(4):399-407罗洁 王勇病原生物学4.557
58A  novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits   weight-lowering and diabetes-protective effects.
Eur   J Med Chem. 2017 Sep 29;138:1158-1169周洁 

林海燕 黄文龙


59AEG-1  induces gastric cancer metastasis by upregulation of eIF4E expression.
J   Cell Mol Med. 2017 Dec;21(12):3481-3493吴圣洁 王雪融 黄文斌药理学4.499
60Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC.
J   Cell Sci. 2017 Mar 15;130(6):1027-1036尤慧梁秀彬病理生理学4.431
61Folliculin  interacts with Rab35 to regulate EGF-induced EGFR degradation
Front   Pharmacol. 2017 Sep 26;8:688郑建超 杜军 张玉杰生理学4.4
62Interleukin-6  inducesDEC1, promotes DEC1 interaction with RXRα and suppresses the expression of PXR, CAR and their target genes
Front   Pharmacol. 2017 Nov 28;8:866宁睿杨俭 刘娓药理学4.4
63MKL1   defines the H3K4Me3 landscape for NF-κB dependent inflammatory response.
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64Genetic  polymorphism and evolutionary differentiation of Eastern Chinese Han: a   comprehensive and comparative analysis on KIRs.
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65Exposure  of pregnant mice to triclosan impairs placental development and nutrient transport
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66Characterization   and genomic study of phiKMV-Like phage PAXYB1 infecting   Pseudomonas aeruginosa.
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67Multiplex   Reverse-Transcription Loop-Mediated Isothermal Amplification Coupled with   Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus.
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68Role   of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis.
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69Protein   arginine methyltransferase 1 (PRMT1) represses MHC II transcription in   macrophages by methylating CIITA.
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70Elevated   serum antibody against Schistosoma japonicum HSP60 as a promising biomarker   for liver pathology in schistosomiasis.
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71Multicolor   bioimaging with biosynthetic zinc nanoparticles and their application in   tumor detection.
Sci   Rep. 2017 Mar 27;7:45313.康雁君 张根 Zhao X
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72Silencing   salusin-β attenuates cardiovascular remodeling and hypertension in   spontaneously hypertensive rats.
Sci   Rep. 2017 Feb 23;7:43259任兴胜朱国庆生理学4.259
73Boronic   Acid-Modified Magnetic Fe3O4@mTiO2 Microspheres for Highly Sensitive and   Selective Enrichment of N-Glycopeptides in Amniotic Fluid.
Sci   Rep. 2017 Jul 4;7(1):4603石中华 

朱云霞 吴金道


74Topographic   relationship between root apex of mesially and horizontally impacted mandibular third molar and lingual plate: cross-sectional analysis using   CBCT.
Sci   Rep. 2016 Dec 19;6:39268王东苗高隽 吴煜农神经生物学4.259
75Postpartum   estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30 
Eur   Neuropsychopharmacol. 2017 Aug;27(8):759-772杨蓉 陈玲生理学4.239
76CRH   promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling   pathway and VEGF-induced tumor angiogenesis.
Mol   Carcinog. 2017 Nov;56(11):2434-2445方先骏李胜男 武彪药理学4.185
77Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental   abnormalities in female offspring.
Toxicol   Sci. 2017 Feb;155(2):409-419冯雪娇 陈玲生理学4.081
78Exposure   of pregnant mice to triclosan causes insulin resistance via thyroxine reduction.
Toxicol   Sci. 2017 Nov 1;160(1):150-160华旭 陈玲 孙鹏生理学4.081
78FERM  domain phosphorylation and endogenous 3'UTR are not essential for regulating the function and subcellular localization of polarity protein Crumbs. 
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79Downregulation   of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing  PI3K/Akt/GSK3β pathway.
CNS   Neurosci Ther. 2017 Sep;23(9):736-747朱朱杨俭药理学3.919
80Microcystin-LR   promotes epithelial-mesenchymal transition in colorectal cancer cells through   PI3-K/AKT and SMAD2
Toxicol   Lett. 2017 Jan 4;265:53-60.任岩 王婷细胞生物学3.858
81iTRAQ-based   quantitative proteomic analyses of high grade esophageal squamous   intraepithelial neoplasia
Proteomics   Clin Appl. 2017 Dec;11(11-12)1600167张菁菁祝辉 冯亚东组织胚胎学3.814
82Involvement   of pregnane X receptor in the suppression of carboxylesterases by metformin   in vivo and in vitro, mediated by the activation of AMPK and JNK signaling   pathway.
Eur   J Pharm Sci. 2017 May 1;102:14-23. 单恩芳杨俭 熊晶药理学3.765
83The   role of miR-21371 cluster in resistance to   deltamethrin in Culex pipiens pallens.
Insect   Biochem Mol Biol. 2017 May;84:15-22过琴沈波 朱昌亮病原生物学3.756
84PPAR-γ   agonist ameliorates liver pathology accompanied by increasing regulatory B   and T cells in high-fat-diet mice.
Obesity   (Silver Spring). 2017 Mar;25(3):581-590.徐志鹏季旻珺病原生物学3.614
85Lactobacillus   paracasei modulates LPS-induced inflammatory cytokine release by  monocyte-macrophages via the up-regulation of negative regulators of   NF-kappaB signaling in a TLR2-dependent manner.
Cytokine.   2017 Apr;92:1-11孙可一季晓辉免疫学3.488
86FTY720   ameliorates renal fibrosis by simultaneously affecting leucocyte recruitment and TGF-β signalling in fibroblasts.
Clin   Exp Immunol. 2017 Oct;190(1):68-78田通关 周洪 施冬艳免疫学3.41
87Correlation   between Trop2 and amphiregulin coexpression and overall survival in gastric   cancer.
Cancer   Med. 2017 May;6(5):994-1001赵薇 冯振卿 朱进病理学3.362
88Preliminary   characterization of putative structural cuticular proteins in the malaria   vector Anopheles sinensis.
Pest   Manag Sci. 2017 Dec;73(12):2519-2528周丹沈波病原生物学3.253
89Myocardial   Ischemic Postconditioning Promotes Autophagy against Ischemia Reperfusion  Injury via the Activation of the nNOS/AMPK/mTOR Pathway
Int   J Mol Sci. 2017 Mar 11;18(3)614郝茂娟 李庆平 胡亮药理学3.226
90Superoxide   Anions and NO in the Paraventricular Nucleus Modulate the Cardiac Sympathetic   Afferent Reflex in Obese Rats.
Int   J Mol Sci. 2017 Dec 27;19(1). pii: E59.陆清波周业波生理学3.226
91Osthole   pretreatment alleviates TNBS-induced colitis in mice via both   cAMP/PKA-dependent and independent pathways.
Acta   Pharmacol Sin. 2017 Aug;38(8):1120-1128孙武李皓病理生理学3.223
92Synthesis   and biological evaluation of novel aliphatic acid-conjugated antimicrobial   peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability.
Amino   Acids. 2017 Nov;49(11):1831-1841张博 

林海燕 黄文龙


93Pro-apoptotic   cationic host defense peptides rich in lysine or arginine to reverse drug  resistance by disrupting tumor cell membrane.
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林海燕 黄文


94MiR-143 regulates the proliferation and migration of osteosarcoma cells through  targeting MAPK7.
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95Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma  japonicum.
Parasit   Vectors. 2017 Jun 24;10(1):306陈琳陈琳病原生物学3.035
96Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice.
Parasit   Vectors. 2017 Oct 2;10(1):453骆晓凤 季旻珺病原生物学3.035
97Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and   oxidative stress in mouse hypothalamus.
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98Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure
Behavioural   Brain Research 321 (2017) 69–78殷梦媚肖明 吴婷药理学3.002
99Paeoniflorin  Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and  Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through   Upregulation of SOCS3 in Diabetic Retinopathy.
Inflammation.   2017 Oct;40(5):1475-1486朱素华 李庆平 袁志兰药理学2.955
100Liver Regeneration Is Impaired in Mice with Acute Exposure to a Very Low   Carbohydrate Diet.
Dig   Dis Sci. 2017 May;62(5):1256-1264陈浩李皓病理生理学2.875
101Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene.
PLoS   One. 2016 Nov 18;11(11):e0166692尹业韩晓生物化学与分子生物学2.806
102Ginkgolide B and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates
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103GPER Agonist G1 Attenuates neuroinflammation and dopaminergic neurodegeneration in Parkinson disease.
Neuroimmunomodulation.   2017;24(1):60-66管静范益 张吉药理学2.674
104Aquaporin-4   mediates the suppressive effect of lipopolysaccharide on hippocampal neurogenesis.
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105Bmi-1 plays a critical role in the protection from acute tubular necrosis by   mobilizing renal stem/progenitor cells.
Biochem   Biophys Res Commun. 2017 Jan 22;482(4):742-749吕仙辉靳建亮人体解剖学2.466
106MKL1   links epigenetic activation of MMP2 to ovarian cancer cell migration and invasion.
Biochem   Biophys Res Commun. 2017 Jun 3;487(3):500-508徐文萍 吴晓燕 徐涌机能实验室2.466
107Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory   element binding protein 1c.
Biochem   Biophys Res Commun. 2017 Jan 22;482(4):720-726尹业 朱云霞 李杰生物化学与分子生物学2.466
108miR-130b-3p   inhibits cell invasion and migration by targeting the Notch ligand Delta-like   1 in breast carcinoma.
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109PD149163   induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
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114Long-term   effects of repeated superovulation on the uterus and mammary gland in rhesus   monkeys.
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125Oridonin   induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells.
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126Inferring   Alcoholism SNPs and Regulatory Chemical Compounds Based on Ensemble Bayesian   Network.
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