陈芳

时间:2017-10-12浏览:1180

 

 

陈芳,女,澳门新葡8455最新网站生物化学与分子生物学博士。目前就职于澳门新葡8455最新网站澳门新葡8455最新网站生物化学与分子生物学系任教,在江苏省人类功能基因组学重点实验室中从事科研工作。

研究方向糖尿病发病机制的研究

邮箱chenfang@njmu.edu.cn

科研成果

主要论著(近三年):

1、Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, Zhou W, Zhu Y, Sun Y, Shi Y, Bleich D, Han X. Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models. Diabetologia. 2016; 59: 316-24.

2、Chen F, Liu J, Wang Y, Wu T, Shan W, Zhu Y, Han X. Aldosterone induces clonal β-cell failure through glucocorticoid receptor. Sci Rep.2015; 5: 13215.

3、Xu YM1, Wang HJ1, Chen F1, Guo WH1, Wang YY1, Li HY, Tang JH, Ding Y, Shen YC, Li M, Xuan WY, Liu LH, Wang J, Wang XR, Gao ZJ, Liang XB, Su DM. HRD1suppressesthegrowthandmetastasisofbreastcancercellsbypromotingIGF-1Rdegradation. Oncotarget. 2015; 6: 42854-67.(共同第一作者)

4、Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, Chen F, Han X. Lentinan protects pancreatic β cells from STZ-induced damage. J Cell Mol Med. 2016; 20: 1803-12.(共同通讯作者)

5、Wu T, Xiang J, Shan W, Li M, Zhou W, Han X, Chen F. Epigallocatechin-3-Gallate Inhibits Ethanol-Induced Apoptosis Through Neurod1 Regulating CHOP Expression in Pancreatic β-Cells. Anat Rec (Hoboken). 2016; 299: 573-82. (通讯作者)

6、Wang H, Wang X, Zhu Y,Chen F, Sun Y, Han X. Increased androgen levels in rats impair glucose-stimulated insulin secretion through disruption of pancreatic beta cell mitochondrial function. J Steroid Biochem Mol Biol. 2015; 154: 254-66.

7、Wang Q, Wang N, Dong M,Chen F, Li Z, Chen Y. GdCl3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice. Clin Sci (Lond). 2014; 127: 91-100.

其他论著:

1.Chen F, Zhu YX, Tang XY, Sun YD, Jia WP, Sun YJ, Han X.Dynamic regulation of PDX-1 and FoxO1 expressionby FoxA2 inpancreatic β-cells treated with dexamethasone. Endocrinology, 2011, 152: 1779-88.

2.Shen H, Xu W, Luo W, Zhou L, Yong W, Chen F, Wu C, Chen Q, Han X. Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma. Exp Hematol, 2011, 39(5):558-569.

3.ChenF, Zhou XH, Lin Y, Jing CW, Yang T, Ji Y, Sun YJ,HanX. Resveratrol prevents interleukin-1β-induced pancreatic β-cells dysfunction. Journal of Biomedical Research, 2010, 24: 381-388.

4.Zhang X, Yong W, Lv J, Zhu Y, Zhang J, Chen F, Zhang R, Yang T, Sun Y, Han X. Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. Endocrinology, 2009, 150: 4065-73.

5.Chen F, Lu JC, Xu HR, Huang YF, Lu NQ. Preliminary investigations on the standardisation and quality control for the determination of c-glutamyltranspeptidase activity in seminal plasma. Andrologia, 2007, 39: 1-6.

6.Chen F, Lu JC, Xu HR, Huang YF, Lu NQ. Chymotrypsin effects on the determination of sperm parameters and seminal biochemistry markers. Clin Chem Lab Med, 2006, 44: 1335–1339.

7.Lu JC, Chen F, Xu HR, Huang YF, Lu NQ. Standardization and Quality Control for Determination of Fructose in Seminal Plasma. Journal of Andrology, 2007, 28: 207-213.

8.Lu JC, Chen F, Xu HR, Huang YF, Lu NQ. Preliminary investigations on the standardization and quality control for the determination of acid phosphatase activity in seminal plasma. Clinica Chimica Acta, 2007, 375: 7681.

9.Lu JC, Chen F, Xu HR, Wu YM, Xia XY, Huang YF, Lu NQ. Is flow cytometry really adapted to the determination of sperm concentration? Scand J Clin Lab Invest, 2006, 67: 1–8.

10.Xu HR, Lu JC, Chen F, Huang YF, Yao B, Lu NQ. THE EFFECT OF CHYMOTRYPSIN ON THE DETERMINATION OF TOTAL ALPHA-GLUCOSIDASE ACTIVITY IN SEMINAL PLASMA AND THE CORRELATION BETWEEN ALPHA-GLUCOSIDASE LEVEL AND SEMEN PARAMETERS. Archives of Andrology, 2006, 52: 441-6.

承担和参与科研项目情况:

1、项目负责人:(1)国家自然科学基金青年科学基金项目:E3 泛素连接酶 Synoviolin 对胰岛β细胞功能的影响,项目批准号81200558,起止时间 2013.01-2015.12;已结题。(2)国家自然科学基金面上项目:SCD12型糖尿病中对胰岛β细胞功能的保护作用及机制研究,项目批准号81670705,起止时间 2017.01-2020.12;主持。

2、项目参与者:国家自然科学基金重点项目(81130013)和国家自然科学基金面上项目(8137088

XML 地图 | Sitemap 地图