熊晶

时间:2017-09-19浏览:258

熊晶,博士,副教授,硕士生导师

研究方向:代谢综合征的转录调控机制和药物靶标

地址:南京市汉中路140号药理学系

邮编:210029

电话:025-86869408

Email:xiong.jing@njmu.edu.cn


熊晶,女,198112月出生。副教授,硕士生导师。Neurochem ResClin Exp Pharmacol PCell Biochem BiophysJ Pharm PharmacolSCI期刊审稿专家。

代表性论文:(*为第一作者,#为通讯作者)

1.Wenjing Luo*, Yu Xin, Xia Zhao, Feng Zhang, Changqing Liu, Hongwei Fan, Tao Xi#,Jing Xiong#.Suppression of Carboxylesterases by Imatinib Mediated by the Downregulation of Pregnane X Receptor.Br J Pharmacol.2017;174(8):700-717

2.Enfang Shan*, Zhu Zhu, Shuangcheng He, Dongbao Chu, Dinghao Ge, YunranZhan, Wei Liu, Jian Yang#,Jing Xiong#.Involvement of Pregnane X Receptorin the suppression of carboxylesterases by metformin in vivo and in vitro,mediated by the activation of AMPK and JNK signaling pathway.Eur J PharmSci.2017; 102: 14-23

3.Shujuan Pan*, Yunlong Tan, Shangwu Yao, Xiaoyan Zhao,JingXiong#.Serum high-sensitivity C-reactive protein: A delicate sentinel elevated in drug-free acutely agitated patients with schizophrenia.Psychiatry Res. 2016;246:89-94.

4.Jing Xiong*, Huan Yang, Wenjing Luo, Enfang Shan, Jie Liu, Feng Zhang, Tao Xi#,Jian Yang#. The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1.Pharmacol Res. 2016; 105:121-133.

5.Huan Yang*,Jing Xiong*, Wenjing Luo, Jian Yang#, Tao Xi#.8-Methoxypsoralen induces intrinsic apoptosis in HepG2 cells: Involvement of reactive oxygen species generation and ERK1/2 pathway inhibition.Cell Physiol Biochem. 2015;37(1):361-74.

6.Yamin Liu*, Wenjing Luo, Huan Yang, Wei Fang, Tao Xi, Yunman Li#,Jing Xiong#.Stimulation of Nitric Oxide Production contributes to the Antiplatelet and Antithrombotic Effect of New Peptide pENW (pGlu-Asn-Trp).Thromb res. 2015;136(2):319-327

7.Jing Xiong*,Huan Yang, Lili Wu, Wei Shang, Enfang Shan, Wei Liu, Gang Hu,Tao Xi, Jian Yang#. Fluoxetine suppresses AMP-activated protein kinase signalingpathway to promote hepatic lipid accumulation in primary mousehepatocytes.Int J Biochem Cell Bio, 2014;54: 236–244

8.Jing Xiong*,Wei Shang, LiliWu, Ruini Chen, Wei Liu,Rui Ning, Gang Hu, Jian Yang#. Glucose dominates the regulation of carboxylesterases induced bylipopolysaccharide or interleukin-6 in primary mouse hepatocytes.Life sci, Sep 2014;112: 41-48

9.Jing Xiong*,Li Bai*, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong#,Yunman Li#.New peptide pENW (pGlu-Asn-Trp) inhibitsplatelet activationvia attenuating Akt phosphorylation.Eur J Pharm Sci,2012;45:552-558

10.Jing Xiong*,Virginia M. Miller#,Yunman Li, MuthuvalJayachandran. Microvesicles at the crossroads between infection and cardiovascular diseases.J CardiovascPharmacol.2012;59(2):124-132

11.Jing Xiong*,Virginia M. Miller#, Larry W. Hunter, Yunman Li#, MuthuvelJayachandran.Leukocyte- and Platelet-derived Microvesicle Interactions following In Vitro and In Vivo Activation of Toll-like Receptor 4 by Lipopolysaccharide.PloS One,Sep 2011;6(9):e25504.

12.Jing Xiong*,Wei Fang, WeirongFang, Li Bai,JianliHuo, Yi Kong,Yunman Li#.Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp).J Pharm Pharmacol.2009;61(1):89-94.

主持项目情况:

1.国家自然科学基金青年基金项目(No. 81302855):LPSIL-6调控代谢性核受体及羧酸酯酶与糖尿病药物代谢异常相关性研究23万元

2.江苏省自然科学基金青年基金项目(No. BK2012446):选择性5-羟色胺再摄取抑制剂对肝脏脂肪代谢的调节作用及机制20万元


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