范益

时间:2016-03-17浏览:439

范益,副教授,医学博士,硕士生导师

澳门新葡8455最新网站药理学系副主任(主持工作)

科学研究方向:神经药理

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166

电话:02586869338

传真:02586869338

电邮:yfan@njmu.edu.cn



简介

主要研究方向为神经精神疾病的病理机制和药物治疗,尤其是胶质细胞的作用及其意义。围绕神经精神类疾病(帕金森病、抑郁症和脑卒中等)中胶质细胞的病理损伤机制和神经保护等开展研究。主持国家自然科学基金面上项目3 项、江苏省教育厅重大项目1 项;在Brain Struct FunctAging CellNeurobiol AgingNeuroscienceSCI期刊发表多篇第一作者或通讯作者文章。


教育背景及工作经历

1997/09 - 2002/07,澳门新葡8455最新网站,临床医学,学士

2002/09 - 2007/07,澳门新葡8455最新网站,药理学,博士

2007/09 - 2011/01,澳门新葡8455最新网站,澳门新葡8455最新网站药理学系,讲师

2011/01 - 至今,澳门新葡8455最新网站,澳门新葡8455最新网站药理学系,副教授

2011/11 – 2013/08Georgia Regents UniversityMedical College of Georgia,博士后

 

学术兼职

江苏省药理学会理事,江苏省药理学会青年工作委员会副主任委员,中国神经学会胶质细胞分会委员,江苏省药理学会教学专委员会委员。

 

承担科研课题

1. 国家自然科学基金面上项目、81673408、水通道蛋白4调节星形胶质细胞对α-synuclein的清除在帕金森病发病机制中的作用、2017/01-2020/1254万元、进行中、主持。

2. 国家自然科学基金面上项目、81173032、水通道蛋白4调节帕金森病不同亚群多巴胺能神经元损伤易感性差异的研究、2012/01-2015/1260万元、已结题、主持。

3. 江苏省高校自然科学研究计划重大项目、11KJA310003AQP4对胶质传递的作用及其与帕金森病的相关性研究、2012/01-2014/12、·5万元、已结题、主持。

4. 国家自然科学基金青年项目、30701017、水通道蛋白4与帕金森病的相关性研究、2008/01-2010/1227万元、已结题、主持。

 

近五年代表性论文、专利

1. Hua Y, Yang BB, Chen Q, Zhang J, Hu J,Fan Y*.Activation of α7 nicotinic acetylcholine receptor protects against 1-methyl-4-phenylpyridinium-induced astroglial apoptosis.Front CellNeurosci. 2019; 13:507. doi: 10.3389/fncel.2019.00507.

2. Hua J, Yin N, Xu S, Chen Q, Tao TT, Zhang J, Ding JH, Fan Y*, Hu G*. Enhancing the astrocytic clearance of extracellular a-synuclein aggregates by Ginkgolides attenuates neural cell injury. Cell Mol Neurobiol. 2019; 39: 1017-1028.

3.  Xu S, Yang B, Tao T, Zhang J, Liu Y, Hu J, Fan Y*, Zhang G*. Activation of α7-nAChRs protects SH-SY5Y cells from 1-methyl-4-phenylpyridinium-induced apoptotic cell death via ERK/p53 signaling pathway. J Cell Physiol. 2019;234:18480–18491.

4.  Hua J, Yin N, Yang B, Zhang J, Ding JH, Fan Y*, Hu G*.Ginkgolide B and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates. Biomed Pharmacother. 2017;96:792-797.

5.  Guan J, Yang BB, Fan Y*, Zhang J*. GPER Agonist G1 Attenuates neuroinflammation and dopaminergic neurodegeneration in Parkinson disease. Neuroimmunomodulation, 2017;24:60-66.

6.  Liang R, Yong S, Huang X, Kong H, Hu G, Fan Y*.Aquaporin-4 mediates the suppressive effect of lipopolysaccharide on hippocampal neurogenesis. Neuroimmunomodulation 2016;23:309-317

7.  Sun HB, Liang R, Yang BB, Zhou Y, Liu MD, Fang F, Ding JH, Fan Y*, Hu G*. Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson‘s disease, Neuroscience, 2016, 317: 65-75.

8.  Zhang J, Yang BB, Sun HB, Zhou Y, Liu MD, Ding JH, Fang F, Fan Y*, Hu G. Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson ‘s disease, Neurosci Lett, 2016, 614: 7-15.

9.  Fan Y, Kong H, Ye XH, Ding JH, and Hu G*. ATP-sensitive potassium channels: uncovering novel targets for treating depression, Brain Struct Funct, 2016; 221(6):3111-22.

10. Zhang J, Li Y, Chen ZG, Dang H, Ding JH, Fan Y*, Hu G. Glia Protein Aquaporin-4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze, CNS Neurosci Ther,2013, 19: 937-44.

11.  Fan Y, Liu M, Wu X, Wang F, Ding J, Chen J, Hu G*. Aquaporin-4 promotes memory consolidation in Morris water maze. Brain Struct Funct. 2013; 218: 39-50.

12.  Fan Y, Li C, Guo J, Hu G, Wu G*. A single lys residue on the first intracellular loop modulates the endoplasmic reticulum export and cell-surface expression of alpha2A-adrenergic receptor. PLoS One. 2012; 7: e50416.

13.  Chi Y#, Fan Y#, He L, Liu W, Wen X, Zhou S, Wang X, Zhang C, Kong H, Sonoda L, Tripathi P, Li CJ, Yu MS, Su C*, Hu G. Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. Aging Cell. 2011; 10: 368-382.

14.  Wei Z1 Zhang M, Li C, Huang W, Fan Y, Guo J, Khater M, Fukuda M, Dong Z, Hu G, Wu G*.Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs.Cell Rep. 2019 Jul 9;28(2):554-566.e4.

15.  Qiao C, Zhang Q, Jiang Q, Zhang T, Chen M, Fan Y, Ding J, Lu M, Hu G*.Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease. J Neuroinflammation. 2018 Jul 2;15(1):193.

16.  Lv Y, Dai W, Ge A, Fan Y, Hu G, Zeng Y*.Aquaporin-4 knockout mice exhibit increased hypnotic susceptibility to ketamine.Brain Behav. 2018 Jun;8(6):e00990.

17.  Li C, Wei Z, Fan Y, Huang W, Su Y, Li H, Dong Z, Fukuda M, Khater M, Wu G*. The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs. Cell Rep. 2017 Oct 24; 21(4):1089-1101.

18.  Liu Y, Hao S, Yang B, Fan Y, Qin X, Chen Y*, Hu J*. Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model. Biochem Pharmaco. 2017 Sep 15; 140:115-123.

19. Kong H*, Zeng XN, Fan Y, Yuan ST, Ge S, Xie WP, Wang H, Hu G. Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis. CNS Neurosci Ther. 2014; 20: 391-402.



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