刘文涛

来源:澳门新葡8455手机版 发布者:张愉悦发布时间:2015-11-30浏览次数:6968

刘文涛  教授 ,理学 博士,博士生 导师

科学研究方向

慢性疼痛的发病机制与药物治疗

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166

电话:025-86869407

电邮:wtliu@njmu.edu.cn


简介

现为澳门新葡8455最新网站澳门新葡8455最新网站药理学系教授。主要研究方向为慢性疼痛的发病机制与药物治疗。过去几年在The Journal of Neuroscience、Cancer Research、FASEB Journal、Pain、Anesthesiology,Journal of Neuroinflammation等SCI杂志上以第一作者和通讯作者身份,发表20多篇SCI文章。现任中国药理学会麻醉药理专业委员常委,中国药理学会肾脏药理专业委员会常委,中国研究型医院麻醉专业委员会委员,江苏省神经免疫学会副主任委员,江苏省医学会疼痛医学委员会委员。承担国家自然科学基金多项。

 

教育背景及工作经历

 1994-1998      山东医科大学,药学                           本科

 1998-2001      中国药科大学  心血管药理                   硕士

 2002-2005      中国药科大学  微生物制药与生化制药  博士

 2005-2007      澳门新葡8455最新网站   药理学系                      讲师

 2007-2010      美国帕克医学研究所                            博士后研究

 2010-至今       澳门新葡8455最新网站   药理学系                      教授


学术兼职

现任中国药理学会麻醉药理专业委员常委,中国药理学会肾脏药理专业委员会常委,中国研究型医院麻醉专业委员会委员,江苏省神经免疫学会副主任委员,江苏省医学会疼痛医学委员会委员,南京医学会疼痛医学委员会委员


承担科研课题

1. 国家自然科学基金面上项目,81471142,选择性调控AMPKα1及α2不同亚型实现能量再平衡治疗神经病理性疼痛,2014/1-2018/12,70万,在研

2. 国家自然科学基金面上项目,81171697,K-ATP通道调控神经病理性疼痛-DRG与脊髓机制研究,2011/1-2015/12,58万,已结题

3. 国家自然科学基金青年科学基金项目,30901401,EphrinB-EphB 信号系统调控吗啡成瘾及耐受-脊髓与初级感觉神经元机制研究,2009/1-2012/12,32万,已结题


 近五年代表性论文、专利

1. Yi-Xin Fan, Cheng Qian,Bingqian Liu, Chaoyu Wang, Haijiao Liu, XiuxiuPan, PengTeng Liang Hu, Guangqin Zhang, Yuan-Han, Mi Yang, Xue-Feng Wu and Wen-Tao Liu *. Induction of suppressor of cytokine signaling 3 via HSF-1-HSP70-TLR4 axis attenuates neuroinflammation and ameliorates postoperative pain. Brain, Behavior, and Immunity.  2018 Feb;68:111-122. doi: 10.1016 (IF=6.3)

2. Yan Zhang?, Gao-Jian Tao?, Liang Hu, Jie Qu, Yuan Han, Guangqin Zhang, Yanning Qian, Chun-Yi Jiang* and Wen-Tao Liu*. Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord. Journal of Neuroinflammation, 2017. 201714:211 10.1186/s12974-017-0983-6  (IF=5.1)

3. Jie Qu  , Xue-You Tao , Peng Teng , Yan Zhang, Ci-Liang Guo , Liang Hu , Yan-Ning Qian , Chun-Yi Jiang* and Wen-Tao Liu*. Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation. Journal of Neuroinflammation, 2017. DOI : 10.1186/s12974-017-0997-0  (IF=5.1)

4. Lai Jiang,# Cai-Long Pan,#  Chao-Yu Wang, Bing-Qian Liu, Yuan Han,  Liang Hu, Lei Liu,  Yang Yang, Jun-Wei Qu and Wen-Tao Liu *. Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats. Journal of Neuroinflammation, 2017. 14:74 2017 Aug 31. doi:  10.1186/s12974-017-0947-x  (IF=5.1)

5. Xiang yuYang, Guiqin He,Xiaoyun Zhang,Lu Chen,Yue Kong, Wei Xie, Zhengping Jia, Wen-Tao Liu *and Zikai Zhou*  Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain. Neuropharmacology. 2017 Oct;125:284-294. doi: 10.1016(IF=5.1)

6. Hai-Jiao Liu?, Xiu-Xiu Pan?, Bing-Qian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yi-Xin Fan, Yu-Lin Tang and Wen-Tao Liu*. Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. Journal of Neuroinflammation, 2017. 14:74 DOI: 10.1186  (IF=5.1)

7. Hong ZW, Tian YJ, Qi MW, Li YC, Du TM, Chen L*, Liu WT*, Chen L, Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons, Front Molecular Neuroscience, 2016, 9: 77(IF=5.4)

8. Wen-Ling Dai, Feng Xiong, Bing Yan, Zheng-Yu Cao, Wen-Tao Liu*, Ji-Hua Liu*, Bo-Yang Yu, Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord, Scientific Reports, 2016, 6: 38746(IF=5.1)

9. Pan YB, Sun XD, Jiang L, Hu L, Kong H, Han Y, Qian C, Song C, Qian YN, Liu WT*, Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation, Journal of Neuroinflammation, 2016, 13(1): 294(IF=5.1)

10. Lu LJ#, Pan CL#, Chen L, Hu L, Wang CY, Han Y, Yang YJ*, Cheng ZX*, Liu WT*, AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats, Journal of Molecular Cell Biology, 2016, 1-12(IF=6.5)

11. Cai Y, Kong H, Pan YB, Jiang L, Pan XX, Hu L, Qian YN, Jiang CY*, Liu WT*, Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia, Journal of Neuroinflammation, 2016, 13: 53(IF=5.1)

12. Li JJ, Xu LJ, Deng XT, Jiang CY, Pan CL, Chen L, Han Y, Dai WL, Hu L, Zhang GQ, Cheng ZX, Liu WT*, N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases, Pain, 2016, 157(8): 1711-1723(IF=5.8)

13. Song HY, Han Y, Pan CL, Deng XT, Dai WL, Hu L, Jiang CY, Yang YJ, Cheng ZX, Li F, Zhang GQ, Wu XF, Liu WT*, Activation of adenosine monophosphate-activated protein kinase suppresses neuroinflammation and ameliorates bone cancer pain: involvement of inhibition on mitogen-activated protein kinase, Anesthesiology, 2015, 123(5): 1170-1185(IF=5.8)


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