陈 峰

时间:2015-10-27浏览:10061


 陈峰,教授,医学博士,博士生导师

 澳门新葡8455最新网站副院长、法医学系主任、司法鉴定所所长

 科学研究方向

 法医物证学、心血管损伤和心源性猝死

 联系方式

 通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166

 电话:025-86869342

 传真:025-86862002

 电邮:fchen@njmu.edu.cn



简介

陈峰,教授、博士生导师,澳门新葡8455最新网站副院长,法医学系主任、司法鉴定所所长、法医学科带头人。2015年入选江苏省特聘教授,2016年以项目领军人入选江苏省创新创业团队,2017年江苏省杰出青年基金获得者,2018年入选江苏省“六大人才高峰”和江苏省青蓝工程优秀教学团队,2019年入选国家自然科学基金优秀青年基金项目。目前主持国家自然科学基金项目4项,江苏省级科研项目5项,累计科研经费近一千万元。在学术刊物AJRCCM, Molecular Cell, PNAS, ATVB, ARS, FRBM和法医学TOP期刊FSIGFSIIJLM等发表学术文章70多篇,被《自然》、《科学》和《循环》等杂志引用1000余次;获得国家发明专利3项。特邀在香山会议双清论坛、司法鉴定理论与实践研讨会和全国血管医学大会等作论坛报告。


教育背景及工作经历

教育背景

2007.92011.5  西安交通大学, 法医学(提前攻博), 博士,

2005.92007.7  西安交通大学, 法医学, 硕士

2000.92005.7  西安交通大学, 法医学, 学士

工作经历

2013.10-至今    澳门新葡8455最新网站, 法医学系, 教授、法医学系主任、澳门新葡8455最新网站副院长

2008.6-2013.9  美国佐治亚医学院, 心血管中心,博士后、Research Scientist


学术兼职

担任教育部国家级实验教学示范中心联席会基础医学组副组长,国家资质认定司法鉴定行业评审员,中国遗传学会法医遗传分会委员,江苏省法医病理专业委员会主任委员,江苏省细胞生物与发育遗传学会青年委员会副主委,江苏省人民检察院院外专家、江苏省医疗损害鉴定专家和上海市司法局鉴定专家、南京法医学会副理事长,澳门新葡8455最新网站科协副主席等学术任职。

 

近五年代表性论文、专利

1. Yu Y, Gao Z, Lou J, Mao Z, Li K, Chu C, Hu L, Li Z, Deng C, Fan H, Chen P, Huang H, Yu Y, Ding J, Li D, Chen F. Identification of Serum-Based Metabolic Feature and Characteristic Metabolites in Paraquat Intoxicated Mouse Models. Front Physiol. 2020 Feb 6; 11:65.

2. Yang J, Lin D, Deng CLi Z, Pu Y, Yu Y, Li K, Li DingChen P, Chen F. The Advances in DNA Mixture Interpretation. Forensic Sci Int. 2019 Aug; 301:101-106.

3. Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z.KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell. 2019 Dec 19; 76(6):885-895.e7.

4. Chen P, Deng C, Li Z, Pu Y, Yang J, Yu Y, Li K, Li D, Liang W, Zhang L, Chen F. A microhaplotypes panel for massively parallel sequencing analysis of DNA mixtures. Forensic Sci Int Genet. 2019 May; 40:140-149. 

5. Fu K, Tian S, Tan H, Wang C, Wang H, Wang M, Wang Y, Chen Z, Wang Y, Yue Q, Xu Q, Zhang S, Li H, Xie J, Lin M, Luo M, Chen F, Ye L, Zheng K. Biological and RNA regulatory function of MOV10 in mammalian germ cells. BMC Biol. 2019 May 14; 17(1):39. 

6. Barman SA, Li X, Haigh S, Kondrikov D, Mahboubi K, Bordan Z, Stepp DW, Zhou J, Wang Y, Weintraub DS, Traber P, Snider W, Jonigk D, Sullivan J, Crislip GR, Butcher JT, Thompson J, Su Y, Chen F, Fulton DJR. Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316(5):L784-L797. 

7. Chen P, Zhu W, Tong F, Pu Y, Yu Y, Huang S, Li Z, Zhang L, Liang W, Chen F. Identifying novel microhaplotypes for ancestry inference. Int J Legal Med. 2019 Jul; 133(4):983-988. 

8. Zhang B, Li Z, Li K, Chen P, Chen F.Forensic parameters and mutation analysis of 23 short tandem repeat (PowerPlex? Fusion System) loci in Fujian Han Chinese population.Leg Med (Tokyo). 2019 Mar; 37: 33-36.

9. Li Z, Xu J, Chen P, Yin C, Hu L, Huang H, Li R, Jia D, Chen F. Forensic efficiency and genetic divergence of 30 autosomal InDels in Chinese Han population from Jiangsu province. Forensic Sci Int Genet. 2018 Nov;37:e17-e19.

10. Yin C, Li K, Yu Y, Huang H, Yu Y, Wang Z, Yan J, Pu Y, Li Z, Li D, Chen P, Chen F. Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population. BMC Pulm Med. 2018 Oct 5;18(1):158.

11. Fan H, Huang H, Hu L, Zhu W, Yu Y, Lou J, Hu L, Chen F. The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication. Toxicol Lett. 2018 Aug;292:123-135.

12. Chen P, Yin C, Li Z, Pu Y, Yu Y, Zhao P, Chen D, Liang W, Zhang L, Chen F. Evaluation of the Microhaplotypes panel for DNA mixture analyses. Forensic Sci Int Genet. 2018 Jul;35:149-155.

13. Chen P, Zhu W, Tong F, Pu Y, Yu Y, Huang S, Li Z, Zhang L, Liang W, Chen F. Identifying novel microhaplotypes for ancestry inference. Int J Legal Med. 2018 Jun 23.

14. Li X, Yu Y, Gorshkov B, Haigh S, Bordan Z, Weintraub D, Rudic RD, Chakraborty T, Barman SA, Verin AD, Su Y, Lucas R, Stepp DW, Chen F, Fulton DJR. Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins. Front Immunol. 2018 Jun 12;9:1309.

15. Barman SA, Chen F, Li X, Haigh S, Stepp DW, Kondrikov D, Mahboubi K, Bordan Z, Traber P, Su Y, Fulton DJR. Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Jun 1;197(11):1488-1492.

16. Yin C, Deng C, Qian X, Huang H, Yu Y, Hu L, Chen P, Chen F. The genetic diversity and applicability assessment of autosomal STRs among Chinese populations by a novel Fixation Index and Nei's index. Leg Med (Tokyo). 2018 Mar;31:49-58.

17. Xia Y, Cai PC, Yu F, Xiong L, He XL, Rao SS, Chen F, Yang XP, Ma WL, Ye H. IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC  synthesis in bronchial epithelial cells. Respir Res. 2017 Sep 20;18(1):174.

18. Li R, Hu L, Hu L, Zhang X, Phipps R, Fowler DR, Chen F, Li L. Evaluation of Acute Alcohol Intoxication as the Primary Cause of Death: A Diagnostic Challenge for Forensic Pathologists. J Forensic Sci. 2017 Sep;62(5):1213-1219.

19. Fulton DJR, Li X, Bordan Z, Haigh S, Bentley A, Chen F, Barman SA. Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension. Antioxidants (Basel). 2017 Jul 6;6(3). pii: E54.

20. Yang CH, Yin CY, Shen CM, Guo YX, Dong Q, Yan JW, Wang HD, Zhang YD, Meng HT, Jin R, Chen F, Zhu BF. Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations. Oncotarget. 2017 Jun 13;8(24):39582-39591.

21. Shen CM, Hu L, Yang CH, Yin CY, Li ZD, Meng HT, Guo YX, Mei T, Chen F, Zhu

BF. Genetic polymorphisms of 54 mitochondrial DNA SNP loci in Chinese Xibe ethnic minority group. Sci Rep. 2017 Mar 22;7:44407.

22. Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJR. RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G(+)-bacterial toxins. Biochem Pharmacol. 2017 Mar 1;127:34-45.

23. Yin C, Hu L, Huang H, Yu Y, Li Z, Ji Q, Kong X, Wang Z, Yan J, Yan J, Zhu B, Chen F. Genetic polymorphism and evolutionary differentiation of Eastern Chinese Han: a comprehensive and comparative analysis on KIRs. Sci Rep. 2017 Feb16;7:42486.

24. Hu L, Yu Y, Huang H, Fan H, Hu L, Yin C, Li K, Fulton DJ, Chen F. Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Front Immunol. 2017 Jan 30;7:696.

25. Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp DW, Weintraub NL, Barman SA, Fulton DJR. Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension. Free Radic Biol Med. 2016 Oct;99:167-178.

26. Chen F, Yin C, Dimitropoulou C, Fulton DJ. Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5. Front Physiol. 2016 Jul 19;7:284.

27. Wang Y, Pati P, Xu Y, Chen F, Stepp DW, Huo Y, Rudic RD, Fulton DJ. Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species. PLoS One. 2016 May 11;11(5):e0155075.

28. Pati P, Fulton DJ, Bagi Z, Chen F, Wang Y, Kitchens J, Cassis LA, Stepp DW, Rudic RD. Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice. Hypertension. 2016 Mar;67(3):661-8.

29. Mohamed R, Jayakumar C, Chen F, Fulton D, Stepp D, Gansevoort RT, Ramesh G. Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis. J Am Soc Nephrol. 2016 Mar;27(3):745-65.

30. Hu CT, Yan JW, Chen F, Zhang QX, Wang HD, Yin CY, Fan HT, Hu LL, Shen CM, Meng HT, Zhang YD, Wang H, Zhu BF. Genetic analysis of 15 mtDNA SNP loci in Chinese Yi ethnic group using SNaPshot minisequencing. Gene. 2016 Jan 15;576(1 Pt1):105-8.

31. Chen F, Haigh S, Yu Y, Benson T, Wang Y, Li X, Dou H, Bagi Z, Verin AD, Stepp DW, Csanyi G, Chadli A, Weintraub NL, Smith SM, Fulton DJ. Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones. Free Radic Biol Med. 2015 Dec;89:793-805.

32. Qian XQ, Yin CY, Ji Q, Li K, Fan HT, Yu YF, Bu FL, Hu LL, Wang JW, Mu HF, Haigh S, Chen F. Mutation rate analysis at 19 autosomal microsatellites.Electrophoresis. 2015 Jul;36(14):1633-9.

33. Chen F, Yin CY, Qian XQ, Fan HT, Deng YJ, Zhang YD, Meng HT, Shen CM, Yang CH, Jin R, Zhu BF, Xu P. Single nucleotide polymorphisms of mitochondrial DNA HVS-I and HVS-II in Chinese Bai ethnic group. Electrophoresis. 2015 Mar;36(6):930-6.

34. Chen F, Wang Y, Barman S, Fulton DJ. Enzymatic regulation and functional relevance of NOX5. Curr Pharm Des. 2015;21(41):5999-6008.

35. Yin C, Ji Q, Li K, Mu H, Zhu B, Yan J, Yu Y, Wang J, Chen F. Analysis of 19 STR loci reveals genetic characteristic of eastern Chinese Han population. Forensic Sci Int Genet. 2015 Jan;14:108-9.

36. Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ. NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1704-15.

37. Chen F, Barman S, Yu Y, Haigh S, Wang Y, Black SM, Rafikov R, Dou H, Bagi Z,Han W, Su Y, Fulton DJ. Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med. 2014 Aug;73:201-13.

38. Chen F, Kumar S, Yu Y, Aggarwal S, Gross C, Wang Y, Chakraborty T, Verin AD, Catravas JD, Lucas R, Black SM, Fulton DJ. PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins. PLoS One. 2014 Jul 14;9(7):e99823.

39. Wang Y, Chen F, Le B, Stepp DW, Fulton DJ. Impact of Nox5 polymorphisms on basal and stimulus-dependent ROS generation. PLoS One. 2014 Jul 3;9(7):e100102.

40. Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW. Increasing muscle mass improves vascular function in obese (db/db) mice. J Am Heart Assoc. 2014 Jun 25;3(3):e000854.


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