肖明

时间:2016-02-25浏览:7676

肖 明  教授  博导 

江苏省神经退行性疾病重点实验室PI

科学技术处副处长






学术兼职

中国药理学会神经精神药理专业委员会委员、中国微循环学会神经变性病专业委员会委员、中国医促会认知障碍分会委员。担任International Neuroscience 副主编,Int J Behav Res & Psychol、Int J Clin Exp Neurol 等7种英文期刊编辑,30余种SCI期刊审稿专家;日本科学促进会(JSPS)项目、荷兰NIH重点项目、国家自然科学基金委重大科研仪器项目评审专家。


教育经历:

2002.9–2005.7,  澳门新葡8455最新网站,  药理学,  博士  

1997.9–2001.7,  澳门新葡8455最新网站,  人体解剖和组织胚胎学,硕士

1995.9–1999.7,  澳门新葡8455最新网站,  临床医学,本科


科研与学术工作经历:

2015.10-至今, 澳门新葡8455最新网站澳门新葡8455最新网站药理学系、江苏省神经退行性疾病重点实验室,教授

2012.9-2015.9, 澳门新葡8455最新网站,澳门新葡8455最新网站人体解剖学系,教授

2006.9-2012.8, 澳门新葡8455最新网站,澳门新葡8455最新网站人体解剖学系,副教授

2002.8-2005.6, Lousivlle大学, 神经科学与解剖学系, 访问学者

2001.9-2006.8, 澳门新葡8455最新网站,澳门新葡8455最新网站人体解剖学系,讲师

1995.8-2001.8, 澳门新葡8455最新网站,澳门新葡8455最新网站人体解剖学系,助教


主持科研项目(课题)及人才计划项目情况:

1. 国家自然科学基金面上项目,81871117,星形胶质细胞-神经元线粒体跨细胞转运失稳态介导脑衰老进程中基底前 脑胆碱能退行性变的机制研究,2019.01-2022.12,在研

2. 国家自然科学基金面上项目,81671070,水通道蛋白4在胶质淋巴系统清除功能和3 xTg-AD小鼠病理进程中的作用,2017.01-2020.12,在研

3. 国家自然科学基金面上项目,81271210,水通道蛋白-4在阿尔茨海默病进程中的作用及机制,2013/01-2016/12,已结题

4. 国家自然科学基金面上项目,30971020,水通道蛋白-4对星形胶质细胞功能的调节及其与阿尔茨海默病的相关性研究,2010/01-2012/12,已结题

5. 江苏省普通高校“青蓝工程”学术带头人培养对象


代表性通讯作者论文:

1. Cao X, Xu H, Feng W, Su D, Xiao M. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage. Brain Res Bull.2018 Oct 19;143:83-96. doi: 10.1016/j.brainresbull.2018.10.007.  

2. Wang L, Cao M, Pu T, Huang H, Marshall C, Xiao M. Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice. Int J Neuropsychopharmacol. 2018 Sep 21. doi: 10.1093/ijnp/pyy084.

3. Wang L, Zhang Y, Zhao Y, Marshall C, Wu T#, Xiao M#. Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice. Brain Pathol. 2018 Sep 7. doi: 10.1111/bpa.12656.  

4. Yin M, Pu T, Wang L, Marshall C, Wu T, Xiao M. Astroglial water channel aquaporin 4-mediated glymphatic clearance function: A determined factor for time-sensitive treatment of aerobic exercise in patients with Alzheimer's disease. Med Hypotheses. 2018 Oct;119:18-21. doi: 10.1016/j.mehy.2018.07.016. Epub 2018 Jul 23. PubMed PMID: 30122483.

5. Gao JY, Chen Y, Su DY, Marshall C, Xiao M. Depressive- and anxiety-like phenotypes in young adult APP(Swe)/PS1(dE9) transgenic mice with insensitivity to chronic mild stress. Behav Brain Res. 2018 Nov 1;353:114-123. doi:10.1016/j.bbr.2018.07.007.

6. Chen Y, Yin M, Cao X, Hu G, Xiao M. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain. Aging Dis. 2018 Jun 1;9(3):374-390. doi: 10.14336/AD.2017.0706.  

7. Cao M, Hu PP, Zhang YL, Yan YX, Shields CB, Zhang YP, Hu G, Xiao M. Enriched physical environment reverses spatial cognitive impairment of socially isolated APPswe/PS1dE9 transgenic mice before amyloidosis onset. CNS Neurosci Ther. 2018 Mar;24(3):202-211. doi: 10.1111/cns.12790.  

8. Lan YL, Chen JJ, Hu G, Xu J, Xiao M, Li S#. Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease. Curr Pharm Des. 2017;23(33):4948-4957. doi: 10.2174/1381612823666170714144844.  

9. Cao M, Pu T, Wang L, Marshall C, He H, Hu G, Xiao M. Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice. Brain Behav Immun. 2017 Aug;64:232-243. doi:10.1016/j.bbi.2017.04.009.  

10. Yin M, Chen Y, Zheng H, Pu T, Marshall C, Wu T#, Xiao M#. Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure. Behav Brain Res. 2017 Mar 15;321:69-78. doi: 10.1016/j.bbr.2016.12.034.  

11. Huang H, Nie S, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M. Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice. Age (Dordr). 2016 Aug;38(4):303-322. doi: 10.1007/s11357-016-9929-7.  

12. Xu ZQ, Huang H, Chen YL, Gao YY, Xu J, Marshall C, Cai ZY, Xiao M. Different  Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis. J Alzheimers Dis. 2016;51(1):179-95. doi: 10.3233/JAD-150634.  

13. Chen YL, Wang LM, Chen Y, Gao JY, Marshall C, Cai ZY, Hu G, Xiao M. Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience. 2016 Mar 1;316:178-91. doi: 10.1016/j.neuroscience.2015.12.039.  

14. Xu Z, Xiao N, Chen Y, Huang H, Marshall C, Gao J, Cai Z, Wu T, Hu G, Xiao M. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol Neurodegener. 2015 Nov 2;10:58. doi:10.1186/s13024-015-0056-1.  

15. Huang H, Wang L, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M. Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice. Int J Neuropsychopharmacol. 2015 Jan 7;18(7):pyu116. doi:10.1093/ijnp/pyu116.  

16. Yuan C, Gao J, Guo J, Bai L, Marshall C, Cai Z, Wang L, Xiao M. Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PLoS One. 2014 Sep 19;9(9):e107447. doi: 10.1371/journal.pone.0107447.  

17. Hao L, Huang H, Gao J, Marshall C, Chen Y, Xiao M. The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice. Neurosci Lett. 2014 Jun 13;571:45-9. doi:10.1016/j.neulet.2014.04.038.  

18. Xiao M, Hu G. Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders. CNS Neurosci Ther. 2014 May;20(5):385-90. doi: 10.1111/cns.12267.  

19. Wu Q, Zhang YJ, Gao JY, Li XM, Kong H, Zhang YP, Xiao M, Shields CB, Hu G. Aquaporin-4 mitigates retrograde degeneration of rubrospinal neurons by facilitating edema clearance and glial scar formation after spinal cord injury in mice. Mol Neurobiol. 2014 Jun;49(3):1327-37. doi: 10.1007/s12035-013-8607-3.

20. Xu ZQ, Zhang LQ, Wang Q, Marshall C, Xiao N, Gao JY, Wu T, Ding J, Hu G, Xiao M. Aerobic exercise combined with antioxidative treatment does not counteract moderate- or mid-stage Alzheimer-like pathophysiology of APP/PS1 mice. CNS Neurosci Ther. 2013 Oct;19(10):795-803. doi: 10.1111/cns.12139.  

21. Gu M, Shen L, Bai L, Gao J, Marshall C, Wu T, Ding J, Miao D, Xiao M. Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging. Age (Dordr). 2014 Feb;36(1):129-39. doi: 10.1007/s11357-013-9552-9.  

22. Liu XL, Lu YS, Gao JY, Marshall C, Xiao M#, Miao DS, Karaplis A, Goltzman D, Ding J#. Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms. Mol Neurobiol. 2013 Dec;48(3):590-600. doi: 10.1007/s12035-013-8448-0.  

23. Li X, Gao J, Ding J, Hu G, Xiao M. Aquaporin-4 expression contributes to decreases in brain water content during mouse postnatal development. Brain Res Bull. 2013 May;94:49-55. doi: 10.1016/j.brainresbull.2013.02.004.  

24. Wei S, Xu Z, Gao J, Ding J, Xiao M. Prenatal ethanol exposure does not cause neurological alterations in adult CD1 mice. Neuroreport. 2013 Mar 6;24(4):196-201. doi: 10.1097/WNR.0b013e32835e3258.  

25. Gao J, Tan M, Gu M, Marshall C, Ding J, Hu G, Xiao M. Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLoS One. 2012;7(9):e46379. doi: 10.1371/journal.pone.0046379.  

26. Li L, Xiao N, Yang X, Gao J, Ding J, Wang T, Hu G, Xiao M. A high cholesterol diet ameliorates hippocampus-related cognitive and pathological deficits in ovariectomized mice. Behav Brain Res. 2012 Apr 21;230(1):251-8. doi: 10.1016/j.bbr.2012.02.024.  

27. Yang W, Wu Q, Yuan C, Gao J, Xiao M, Gu M, Ding J, Hu G. Aquaporin-4 mediates astrocyte response to β-amyloid. Mol Cell Neurosci. 2012 Apr;49(4):406-14. doi: 10.1016/j.mcn.2012.02.002.  

28. Cao G, Gu M, Zhu M, Gao J, Yin Y, Marshall C, Xiao M, Ding J, Miao D. Bmi-1 absence causes premature brain degeneration. PLoS One. 2012;7(2):e32015. doi: 10.1371/journal.pone.0032015.  

29. Wu W, Li M, Liu L, Gao J, Kong H, Ding J, Hu G, Xiao M. Astrocyte activation but not neuronal impairment occurs in the hippocampus of mice after 2 weeks of d-galactose exposure. Life Sci. 2011 Sep 12;89(11-12):355-63. doi:10.1016/j.lfs.2011.06.028.  

30. Liu L, Lu Y, Kong H, Li L, Marshall C, Xiao M, Ding J, Gao J, Hu G. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. Int J Neuropsychopharmacol. 2012 Feb;15(1):55-68.  

31. Li L, Ding J, Marshall C, Gao J, Hu G, Xiao M. Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-galactose-injected mice. Behav Brain Res. 2011 Feb 2;217(1):244-7. doi: 10.1016/j.bbr.2010.10.032.  

32. Liu L, Su Y, Yang W, Xiao M, Gao J, Hu G. Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience. 2010 Aug 25;169(2):596-608. doi: 10.1016/j.neuroscience.2010.05.028.  

33. Xiao M, Cao GL, Marshall C, Hu G. Hypothesis: multiple factors are associated with the lack of any beneficial effects of oestrogen-replacement therapy in the late postmenopausal stage. Clin Exp Pharmacol Physiol. 2010 Aug;37(8):873-6. doi:10.1111/j.1440-1681.2010.05400.x.  

34. Su Y, Sun H, Fang J, Hu G, Xiao M. Brain mitochondrial dysfunction in ovariectomized mice injected with D-galactose. Neurochem Res. 2010 Mar;35(3):399-404. doi: 10.1007/s11064-009-0068-8.  

35. Li X, Kong H, Wu W, Xiao M, Sun X, Hu G. Aquaporin-4 maintains ependymal integrity in adult mice. Neuroscience. 2009 Aug 4;162(1):67-77. doi: 10.1016/j.neuroscience.2009.04.044.  

36. Lei M, Su Y, Hua X, Ding J, Han Q, Hu G, Xiao M. Chronic systemic injection of D-galactose impairs the septohippocampal cholinergic system in rats. Neuroreport. 2008 Oct 29;19(16):1611-5. doi: 10.1097/WNR.0b013e3283136a1f.  

37. Wei S, Lei M, Tong M, Ding J, Han Q, Xiao M. Acute baroreceptor unloading evokes Fos expression in anesthetized rat brain. Brain Res Bull. 2008 May 15;76(1-2):63-9. doi: 10.1016/j.brainresbull.2007.12.003.  

38. Lei M, Hua X, Xiao M#, Ding J, Han Q#, Hu G. Impairments of astrocytes are involved in the d-galactose-induced brain aging. Biochem Biophys Res Commun. 2008 May 16;369(4):1082-7. doi: 10.1016/j.bbrc.2008.02.151.

39. Hua X, Lei M, Ding J, Han Q, Hu G, Xiao M. Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose: a potential contribution to Alzheimer's disease processes. Exp Neurol. 2008 Apr;210(2):709-18. doi: 10.1016/j.expneurol.2008.01.009.

40. Zhou J, Kong H, Hua X, Xiao M, Ding J, Hu G. Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice. Neuroreport. 2008 Jan 8;19(1):1-5.  doi: 10.1097/WNR.0b013e3282f2b4eb.  

 #共通讯作者


学术著作:

1. 《阿尔茨海默病》科学出版社, ISBN 978-7-03-043035-9,副主编

2. 《阿尔茨海默病分子生物学》科学出版社, ISBN 978-7-03-047286-1,副主编

3. 《Aquaporins》Springer, ISSN 0065-2598, 参编

4. 《哈里森神经内科学》,北京大学医学出版社,9787030559968,参译


科技获奖

1. 阿尔茨海默病的血管—免疫异常机制研究与调控 2016年度江苏省科学技术奖,三等奖,排名第二

2. 星形胶质细胞在神经退行性疾病发病机制中的作用研究 2016年度江苏省教育科学研究成果,二等奖,排名第一



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